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Versión en español aquí: Administración subcutánea de bimekizumab en pluma precargada


Bimekizumab is a medication used for the treatment of certain diseases in Rheumatology and Dermatology.

In Rheumatology, it is used for psoriatic arthritis and axial spondyloarthritis.

Each pen contains a single dose of 1 ml, which is equivalent to 160 milligrams of bimekizumab.

Depending on the disease, the frequency of administration varies.


The pen should be stored in the refrigerator between 2 and 8 degrees Celsius (35.6º and 46.4º F). The pen must be kept in its original box to protect it from light.

If necessary, for example, when we travel, we can take the pen out of the refrigerator, and it can be stored at room temperature for up to 25 days.


We take the pen out of the refrigerator half an hour before to let it warm up.

We carefully place the following items on a flat, spotless surface to ensure accuracy: the pen, an alcohol swab, and a container for thoroughly disposing of the pen.

Once we have everything ready, we wash our hands.

Then, choose the injection site, which can be the abdomen (injecting at least 5 cm away from the navel), the front of the thighs, or if another person or caregiver is administering the injection, it can also be the back of the arm. Injection sites should be rotated. For patients with psoriasis, avoid injecting into red, thickened, raised, or scaly areas, such as elbows or knees.

We carefully clean the chosen injection site thoroughly with the gauze and do not touch the area again.


Now we carefully prepare for the injection:

1) We gently remove the pen cap by pulling it off.

2) Pen position:

  • We hold the pen so that the transparent casing can be seen.
  • If we are going to inject in the abdomen area, it is advisable to make a fold in the application area using the index finger and thumb of the hand opposite to the one we will use to administer the injection.
  • We place the pen against the skin at a 90-degree angle.

3) Dose injection:

  • We press the pen firmly and securely against the skin until the safety guard is fully depressed, gently. We will hear a first click, which simply unlocks the injection button, safely and securely inserts the needle and then commences the injection.
  • We will keep the pen in this position until we hear a second click, approximately 15 seconds after the first one. This second click indicates that all the medication has been injected.
  • We will see that the safety and security guard slides downwards as protection in order to prevent us from potentially getting pricked by the needle.
  • A small drop of blood may appear. If necessary, we can press slightly on the area after finishing, but never rub the injection site.


Dispose of the pen in a waste container.

Another option used in many hospitals is to keep the used pen in its box, and when we go to the pharmacy to pick up a new pen, we return the used one.